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Henry Brem Selected Research

decanedioic acid- 4,4'- (1,3- propanediylbis(oxy))bis(benzoic acid) copolymer

2/2013Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model.
3/2010Epirubicin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.
5/2006Lactacystin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.
11/2005Local delivery of a synthetic endostatin fragment for the treatment of experimental gliomas.
9/2003Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma.
2/2002Polymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy.

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Henry Brem Research Topics

Disease

95Neoplasms (Cancer)
02/2022 - 02/2002
72Glioma (Gliomas)
04/2022 - 02/2002
51Brain Neoplasms (Brain Tumor)
01/2022 - 07/2002
35Glioblastoma (Glioblastoma Multiforme)
02/2022 - 06/2002
23Gliosarcoma
01/2022 - 02/2002
6Melanoma (Melanoma, Malignant)
02/2022 - 12/2002
6Wounds and Injuries (Trauma)
02/2021 - 05/2003
5Meningioma (Meningiomas)
03/2022 - 06/2002
5Astrocytoma (Pilocytic Astrocytoma)
11/2020 - 06/2002
5Seizures (Absence Seizure)
08/2017 - 02/2005
4Surgical Wound Infection
04/2022 - 10/2008
4Infections
12/2020 - 01/2004
4Pulmonary Embolism
10/2018 - 10/2008
4Oligodendroglioma
09/2013 - 06/2002
3Hydrocephalus (Hydrocephaly)
09/2022 - 01/2006
3Hepatitis C
01/2020 - 01/2018
3Breast Neoplasms (Breast Cancer)
01/2019 - 09/2007
3Edema (Dropsy)
06/2018 - 07/2002
3Neoplasm Metastasis (Metastasis)
12/2013 - 01/2004
3Venous Thrombosis (Deep-Vein Thrombosis)
03/2013 - 10/2008
2Hyperglycemia
04/2022 - 05/2010
2Thrombosis (Thrombus)
01/2022 - 03/2009
2Rhabdoid Tumor (Rhabdoid Tumors)
09/2021 - 01/2018
2Hematologic Neoplasms (Hematological Malignancy)
02/2021 - 01/2020
2Medulloblastoma
02/2021 - 01/2021
2Pain (Aches)
10/2018 - 03/2007
2Spinal Cord Neoplasms (Spinal Cord Tumors)
08/2015 - 08/2005
2Corneal Neovascularization
01/2015 - 11/2005
2Adenocarcinoma
11/2014 - 12/2013
2Renal Cell Carcinoma (Grawitz Tumor)
07/2011 - 09/2007
2Brain Edema (Cerebral Edema)
03/2009 - 07/2002
2Neurologic Manifestations (Neurological Manifestations)
09/2007 - 01/2004
1Hypoxia (Hypoxemia)
01/2022

Drug/Important Bio-Agent (IBA)

29PolymersIBA
02/2015 - 02/2002
27Carmustine (FIVB)FDA Link
11/2019 - 02/2002
26Temozolomide (Temodar)FDA LinkGeneric
01/2022 - 10/2005
19Pharmaceutical PreparationsIBA
02/2021 - 11/2002
11poliferprosan 20 drug combination carmustine (Gliadel)FDA Link
01/2019 - 01/2004
8Paclitaxel (Taxol)FDA LinkGeneric
05/2014 - 06/2002
7Proteins (Proteins, Gene)FDA Link
01/2021 - 03/2007
6decanedioic acid- 4,4'- (1,3- propanediylbis(oxy))bis(benzoic acid) copolymerIBA
02/2013 - 02/2002
5Biomarkers (Surrogate Marker)IBA
01/2021 - 08/2006
5CytokinesIBA
03/2016 - 08/2003
5Interleukin-2 (IL2)IBA
11/2012 - 04/2003
5Antineoplastic Agents (Antineoplastics)IBA
08/2009 - 02/2002
4Dexamethasone (Maxidex)FDA LinkGeneric
04/2022 - 01/2004
4Ribavirin (Virazole)FDA LinkGeneric
02/2021 - 01/2018
4Monoclonal AntibodiesIBA
12/2018 - 01/2016
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2017 - 12/2012
4DNA (Deoxyribonucleic Acid)IBA
08/2015 - 03/2003
4Alkylating AgentsIBA
01/2015 - 10/2004
3Glutamic Acid (Glutamate)FDA Link
02/2022 - 10/2013
3Immune Checkpoint InhibitorsIBA
02/2022 - 01/2018
3Programmed Cell Death 1 ReceptorIBA
02/2022 - 12/2016
3Antiviral Agents (Antivirals)IBA
02/2021 - 01/2019
3Therapeutic UsesIBA
01/2021 - 01/2016
3Cisplatin (Platino)FDA LinkGeneric
10/2017 - 06/2002
3Bevacizumab (Avastin)FDA Link
10/2017 - 07/2012
3AntigensIBA
12/2016 - 01/2014
3EndostatinsIBA
01/2015 - 11/2005
3Doxorubicin (Adriamycin)FDA LinkGeneric
11/2014 - 09/2005
3Anti-Bacterial Agents (Antibiotics)IBA
10/2013 - 11/2005
3CamptothecinIBA
10/2004 - 02/2002
2LuciferasesIBA
02/2022 - 06/2013
2AcriflavineIBA
01/2022 - 11/2017
2Enhancer of Zeste Homolog 2 ProteinIBA
09/2021 - 02/2021
2Histone MethyltransferasesIBA
09/2021 - 02/2021
2Eukaryotic Initiation Factor-4EIBA
02/2021 - 01/2020
2Thymidine KinaseIBA
01/2020 - 02/2015
2GuanosineIBA
01/2019 - 01/2018
2Adrenal Cortex Hormones (Corticosteroids)IBA
01/2018 - 07/2002
2LigandsIBA
01/2018 - 06/2013
2Dendrimers (Dendrons)IBA
12/2016 - 06/2015
2Angiogenesis InhibitorsIBA
01/2016 - 03/2014
2Messenger RNA (mRNA)IBA
01/2016 - 11/2013
2Capsules (Microcapsules)IBA
11/2014 - 04/2011
2Radiation-Sensitizing AgentsIBA
05/2014 - 08/2010
2Minocycline (Cyclops)FDA LinkGeneric
03/2014 - 09/2003
2Glucose (Dextrose)FDA LinkGeneric
07/2012 - 05/2010
2EnzymesIBA
03/2010 - 03/2003
2Irinotecan (Camptosar)FDA LinkGeneric
08/2006 - 10/2004
2polilactofateIBA
01/2006 - 08/2003
114- methyl- 20- oxa- 5,7,14,26- tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa- 1(25),2(26),3,5,8(27),9,11,16,21,23- decaeneIBA
09/2021
1Cyclin-Dependent Kinases (cdk Proteins)IBA
09/2021
1Cyclin D1IBA
09/2021

Therapy/Procedure

59Therapeutics
01/2022 - 07/2002
26Drug Therapy (Chemotherapy)
11/2019 - 10/2002
23Radiotherapy
04/2021 - 01/2004
13Immunotherapy
02/2022 - 04/2003
10Craniotomy
01/2022 - 03/2002
4Microspheres (Microsphere)
05/2014 - 04/2003
3Length of Stay
03/2022 - 08/2015
2Reoperation
09/2022 - 10/2018
2Contraindications
10/2020 - 10/2010
2Injections
11/2012 - 01/2012
2Micro-Electrical-Mechanical Systems
08/2012 - 08/2005
2Oral Administration
03/2010 - 10/2007
1Patient Readmission
03/2022
1Laminectomy
02/2022
1Conservative Treatment
01/2022